Therapy against senescence

StarkAge Therapeutics’ ambition is to delay or halt disease progression and improve the quality of life of patients with age-related diseases associated with the accumulation of senescent cells. We are developing innovative therapies to target senescent cells induced by anticancer treatment.

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StarkAge Therapeutics : Focus on senescence

StarkAge Therapeutics is a pioneering privately held discovery-stage biotechnology company based in Lille, France. It was founded in 2018 by Dr. Thierry Mathieu, with scientific support from Dr. Müge Ogrunc, based on the idea that eliminating disease specific senescent cells using therapy could deliver significant benefits to patients.

Mounting evidence in literature confirms senescent cell accumulation as a hallmark in various aged-related diseases such as idiopathic pulmonary fibrosis, neurodegenerative diseases, metabolic dysfunction or hepatic fibroses. Moreover, senescent cells are accumulated during cancer treatment and are related to  tumor relapse, drug resistance and many others side effects for patients. In this way, StarkAge Therapeutics identifies specific targets of senescent cells and develops therapies to eradicate side effects associated to senescent cancer cells.

The French government has granted StarkAge Therapeutics with the “Jeune Entreprise Innovante” label in recognition for its innovative research. In addition, BPIfrance (the “Banque Publique d’Investissement”) has supported our research pipeline with an initial grant in 2019. In 2021 they granted the prestigious Deeptech label and significant additional non-dilutive financial support.


People die from non-contagious chronic illnesses

ExoCiseTM Platform

StarkAge Therapeutics strategy to identify markers of senescence and design innovative therapies

Research Overview

Each year almost 60M people die from non-contagious chronic illnesses, all of which are linked to aging (World Health Organization). Great progress has been made in recent decades in understanding the molecular mechanisms behind the causes of age-related pathologies, in particular cellular senescence. The persistent accumulation of senescent cells appears to be one of the contributors to aging.

StarkAge Therapeutics was the first team to develop an alternate method for the depletion of senescent cells in age-related pathologies. We believe that selective senescent cell destruction is the key to achieving successful clinical outcomes which will result in a longer lifespan in good health.

StarkAge Therapeutics unique expertise originates from its proprietary biomarker discovery platform, ExoCiseTM, enabling the characterization of senescent cells biomarkers.


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